Research and Publications
The PNB Fund supports basic research on synovial sarcoma. Recent papers published by research teams supported by the PNB Fund include the following:
• Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR. "SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas." Oncogene (2012), 1–7. https://www.ncbi.nlm.nih.gov/pubmed/22797074
• Alan L. Ho, Shyamprasad Deraje Vasudeva, Marick Lae, et al. "PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma." Cancer Research, 2012 Sep 1;72(17):4515-25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432680/
• Barrott JJ, Illum BE, Jin H, Hedberg ML, Wang Y, Grossmann A, Haldar M, Capecchi MR, Jones KB. Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest. 2018 Jan 2;128(1):207-218. doi: 10.1172/JCI94955. Epub 2017 Nov 20. PubMed PMID: 29202462; PubMed Central PMCID: PMC5749548. https://www.ncbi.nlm.nih.gov/pubmed/29202462
• Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW. The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell. 2018 Aug 13;34(2):346-348. doi: 10.1016/j.ccell.2018.07.006. PubMed PMID: 30107180.
• Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca; Cancer Genome Atlas Research Network. Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. Cell. 2017 Nov 2;171(4):950-965.e28. doi: 10.1016/j.cell.2017.10.014. PubMed PMID: 29100075; PubMed Central PMCID: PMC5693358. https://www.ncbi.nlm.nih.gov/pubmed/29100075
The PNB Fund supports basic research on synovial sarcoma. Recent papers published by research teams supported by the PNB Fund include the following:
• Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR. "SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas." Oncogene (2012), 1–7. https://www.ncbi.nlm.nih.gov/pubmed/22797074
• Alan L. Ho, Shyamprasad Deraje Vasudeva, Marick Lae, et al. "PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma." Cancer Research, 2012 Sep 1;72(17):4515-25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432680/
• Barrott JJ, Illum BE, Jin H, Hedberg ML, Wang Y, Grossmann A, Haldar M, Capecchi MR, Jones KB. Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest. 2018 Jan 2;128(1):207-218. doi: 10.1172/JCI94955. Epub 2017 Nov 20. PubMed PMID: 29202462; PubMed Central PMCID: PMC5749548. https://www.ncbi.nlm.nih.gov/pubmed/29202462
• Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW. The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell. 2018 Aug 13;34(2):346-348. doi: 10.1016/j.ccell.2018.07.006. PubMed PMID: 30107180.
• Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca; Cancer Genome Atlas Research Network. Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. Cell. 2017 Nov 2;171(4):950-965.e28. doi: 10.1016/j.cell.2017.10.014. PubMed PMID: 29100075; PubMed Central PMCID: PMC5693358. https://www.ncbi.nlm.nih.gov/pubmed/29100075